Ewing's Sarcoma Treatments: Topotecan + Cyclophoshamide
Basic Information for Topotecan
- Topotecan is also called topotecan hydrochloride, NSC-609699, and Hycamtin.
- It inhibits the action of topoisomerase I, an enzyme that produces reversible single-strand breaks in DNA during DNA replication.
- It is given via IV.
- It is approved by the FDA for ovarian and lung cancers.
Basic Information for Cyclophoshamide
- Cyclophoshamide is also called Cyclo, CPA, CPM, CTX, CYC, CYT, Cytoxan, Procyton, and Neosar.
- It is given via IV or orally.
- It is FDA-approved for many cancers and has been available for decades.
Related Papers
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2000 abstract describing using cyclophosphamide and topotecan for resistant solid tumors; discusses the dosage and side effects.