Ewing's Sarcoma Treatments: Irinotecan + Temozolomide
Basic Information on Irinotecan
- Irinotecan is also called Irinotecan hydrochloride trihydrate, CPT-11 and Camptosar.
- It is in the same family as topotecan and exatecan.
Basic Information on Temozolomide
- Temozolomode is also called TMZ, SCHS2.365, NSC 362856, Temodol and Temodar.
- It is given orally.
- See the FDA label; approved for refractory brain tumors.
- There was a 2003 phase 2 trial at Columbia using temozolomide and thalidomide for leiomyosarcoma.
Previous Results: Ewing's Sarcoma
- 2003 abstract for a Phase 2 of temozolomide in Italy; 2/4 partial responses for extraosseous Ewings, 1/4 partial response for Ewing's in a bone
- 2003 abstract for a Phase 1 trial at Utah (Huntsman) and Memphis, TN (St. Jude); 2 partial responses for Ewing's; the unpublished results are much better (5/8 responses in recurrent Ewing's)
Previous Results: Other Cancers
- 2003 abstract for a Phase 1 trial for recurrent malignant glioma; discusses dosage and side effects
- 2000 abstract and 2000 abstract mouse studies
- 1999 abstract stating that temozolomide is not active in advanced soft tissue sarcomas (Phase 2 trial)
Related Clinical Trial (uses one drug, but not both)
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Multi-center irinotecan Phase 2 trial for refractory solid tumors in children.