Ewing's Sarcoma Treatments: Gemcitabine + Docetaxel

Basic Information on Gemcitabine

Gemcitabine is also called Gemzar.
It has been used successfully with pancreas and non-small cell lung cancer.
It is an antimetabolite.

Basic Information on Docetaxel

Docetaxel is also called Taxotere.
It is used for breast cancer and non-small cell lung cancer.
It is an antineoplastic.

Research Results: Ewing's Sarcoma

2002 poster on gemcitabine and docetaxel in sarcoma; Ewing's sarcoma had a 1/1 response. (University of Michigan Cancer Center)

Research Results: non-Ewing's Sarcoma

2000 summary of trial in Israel, stating that gemcitabine was effective in achieving stabilization of sarcomas resistant to standard chemotherapies; 8/18 partial, minimal or stable sarcomas. (No Ewing's on study)
1999 abstract on gemcitabine for advanced soft tissue sarcomas; the dosage might have been too low for response

Current and Closed Clinical Trials

Gemcitabine and docetaxel Phase 2 trial at MSK in New York City (another description) (for adults); Ewing's sarcoma is not allowed
Gemcitabine and docetaxel Phase 1 trial in New Hampshire. The PI was at MSK. The cycles is 2 weeks long; it is a dose-escalation study of docetaxel (for adults)