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June 2008

The Electronic Sarcoma Update Newsletter, Vol. 5, No. 3

Each of the words or phrases that are underlined and in a bold blue type in ESUN are hyperlinks to websites, documents or articles. Each title in the table of contents, In This Issue, is a link to the specific article. All the external hyperlinks appearing in ESUN were valid when the issue of ESUN was published. If you find any broken links, please send us a note about them. The document hyperlinks typically open PDF documents, so you should have the Adobe Acrobat Reader installed on your system in order to read them. 

 

In This Issue

Feature Articles

Someone has always been there to do what needs to be done

Editorial by Bruce Shriver, PhD 

CTOS Op Ed: The creation of a robust registry of sarcoma patients and biological resources 

Paul A. Meyers, MD  discusses why all of us in the sarcoma community would benefit from the creation of a robust registry of sarcoma patients and biological resources.

Well-differentiated and de-differentiated retroperitoneal liposarcoma: a paradigm for histology specific multimodality therapy

Kerrington Smith, MD, Guy Lahat, MD, Raphael Pollock, MD, PhD and Dina Lev, MD discuss two distinct surgical and multidisciplinary approaches to managing well differentiated and dedifferentiated liposarcomas.  

A Research Study Progress Report: microRNA Deregulation in Mesenchymal Transformation and Sarcomagenesis

Eva Hernando, PhD describes her ongoing research in microDNA deregulation.

Characterization of WWOX tumor suppressor gene in osteosarcoma

Jilong Yang, MD, PhD and Wei Zhang, PhD describe research aimed at determining if the WWOX gene is an important tumor suppressor gene in osteosarcoma.

Participatory Medicine: an End to Rational Ignorance in Medicine

Gilles Frydman discusses why participatory medicine must be a collaborative driven approach to medicine.

An Update on GIST Support International

Lee Ann Lamb  

An Update on  the Jennifer Hunter Yates Sarcoma Foundation

Susan Erickson 

An Update on The Chris Lucas Trust

Lynn Lucas  

A Partial Index to Articles that have Appeared in ESUN

We give an updated partial index to ESUN articles.

Regular Columns

Clinical Trial News 

Tom Swartz describes various clinical trials
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Currently Accepting Eligible Patients (not previously published in ESUN)

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Not Yet Recruiting Patients (not previously published in ESUN)

Odds & Ends

Pointers to resources and abstracts of interesting articles. In this issue: 
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Heart failure associated with sunitinib malate

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Management of Cancer Pain: Basic Principles and Neuropathic Cancer Pain

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Parenting Stress in Pediatric Oncology Populations

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Sarcoma Advocate Claims Inquiry Into Fast-tracking of Avastin Could Hurt Cancer Drug Development

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Better Cancer Cell–Specific Therapies

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Potential Viral Therapy Weapon Is Safe And Effective In Mouse Study

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Researchers in Australia Pinpoint the Function of a Potent Cancer Gene

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Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

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New targets for therapy of sarcoma

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Oncolytics Biotech Inc. Present Positive Phase II Sarcoma Trial Results at ASCO Annual Meeting

Research Corner

Abstracts of recent sarcoma-related research articles. In this issue: 
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Resectable Well-Differentiated versus Dedifferentiated Liposarcomas: Two Different Diseases Possibly Requiring Different Treatment Approaches

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Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

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The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma

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Fas Death Pathway in Sarcomas Correlates with Epidermal Growth Factor Transcription

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Histone Deacetylase Inhibitors Reverse SS18-SSX–Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma

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The Estrogen Receptor Pathway in Rhabdomyosarcoma: A Role for Estrogen Receptor-β in Proliferation and Response to the Antiestrogen 4'OH-Tamoxifen

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Epidermal Growth Factor Receptor Blockade in Combination with Conventional Chemotherapy Inhibits Soft Tissue Sarcoma Cell Growth in Vitro and In Vivo

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Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas

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Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

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Preliminary Data Presented on CP-751,871 in Sarcoma

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Phase I/II Study of Targeted Gene Delivery In Vivo Intravenous Infusions of REXIN-G Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma

Stories of Courage and Hope

Tom Swartz abstracts several inspiring stories we have recently encountered about patients or caregivers that tell of the strength that some are blessed with in dealing with sarcoma. In this issue: 
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Firefighter Renews Battle Against Osteosarcoma With Experimental Treatment

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Minneapolis PR exec hopes to beat odds, survive bout with rare bone cancer

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Ready to Run: Fighting Back from Bout with Cancer

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Teen battling sarcoma hopes to build home for African AIDS orphans

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Wedel Survives Sarcoma, Gets Back In The Game

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Friends, family share memories of teenager who battled cancer

Our Initiatives

Brief descriptions of some of the Liddy Shriver Sarcoma Initiative projects are presented. In this issue:

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Team Sarcoma Event planning is underway as part of the 2008 Team Sarcoma Initiative

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The Faces of Sarcoma Project

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The "Sarcoma Knows No Borders" Bracelet 

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Music CD, The Circle, Benefits Sarcoma Research

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Clinical trial abstracts now exceed 300

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Guest Book

General Information

Disclaimer

Medical Editorial Board and Editorial Staff

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Topics and Feedback

Please send us your recommendations for topics that you would like to see covered in ESUN as well as any other comments or feedback that can be useful to us. We also welcome contributions of essays and articles that are relevant to ESUN and its intended audience

 

V5N3 ESUN Copyright © 2008 Liddy Shriver Sarcoma Initiative.

 

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